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Methods For Detecting Cells Latently
Infected With HIV




NON-CONFIDENTIAL INVENTION SUMMARY
US Provisional Application: US/61/903,799
Priority Date: November 13, 2013


Inventors:
Nicolas Chomont, PhD, Vaccine & Gene Therapy Institute of Florida
Rafick-Pierre Sekaly PhD, Vaccine & Gene Therapy Institute of Florida
Remi Fromentin, PhD, Vaccine & Gene Therapy Institute of Florida

Antiretroviral therapy (ART) reduces HIV replication but does not eradicate HIV.  The persistence of HIV in a small pool or reservoir of long-lived latently infected resting CD4 T cells is a major barrier to complete viral eradication. 

This invention identifies cell surface markers that are preferentially expressed by latently infected CD4 T cells in individuals on suppressive anti-retroviral therapy (ART). These cells can be sorted and used to screen test compounds for potential therapeutic candidates that inhibit or eliminate these cells and ultimately achieve HIV eradication from the body.



Key Words: HIV Reservoir, biomarkers and predictors of latently infected cells,  PD-1 , immune check point blockers , flow cytometry

Publications: Chomont, N., M. El-Far, P. Ancuta, L. Trautmann, F. A. Procopio, B. Yassine-Diab, G. Boucher, M. R. Boulassel, G. Ghattas, J. M. Brenchley, T. W. Schacker, B. J. Hill, D. C. Douek, J. P. Routy, E. K. Haddad, and R. P. Sekaly. 2009. HIV reservoir size and persistence are driven by T cell survival and homeostatic proliferation. Nat Med 15:893-900. PMID:19543283

Chomont, N., S. DaFonseca, C. Vandergeeten, P. Ancuta, and R. P. Sekaly. 2011. Maintenance of CD4+ T-cell memory and HIV persistence: keeping memory, keeping HIV. Curr Opin HIV AIDS 6:30-36. PMID:21242891

Trono, D., C. Van Lint, C. Rouzioux, E. Verdin, F. Barre-Sinoussi, T. W. Chun, and N. Chomont. 2010. HIV persistence and the prospect of long-term drug-free remissions for HIV-infected individuals. Science 329:174-180. PMID:20616270

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